Effect of interferon (IFN-.ALPHA.) on superoxide production from polymorphonuclear leukocytes.
نویسندگان
چکیده
منابع مشابه
Nitric oxide inhibits superoxide production by inflammatory polymorphonuclear leukocytes.
Nitric oxide (NO ⋅) has a complex role in the inflammatory response. In this study, we modified the levels of endogenous NO ⋅ in vivo in an acute model of inflammation and evaluated the interactions between NO ⋅ and superoxide anion ([Formula: see text]) produced by polymorphonuclear leukocytes (PMNs) accumulated in the inflamed area. We injected phosphate-buffered saline (control group), 6 μmo...
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Superoxide anion release from polymorphonuclear leukocytes stimulated by concanavalin A was markedly enhanced by the simultaneous addition of cytochalasin A at concentrations of 2x10-s to 4x10-1M. These concentrations of cytochalasin A did not affect the phagocytosis of diisodecyl phthalate emulsion. These concentrations were far lower than those of cytochalasins B, C, D and E that also enhance...
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The release of superoxide (O2-) by polymorphonuclear leukocytes (PMN) is an important function that contributes to microbial death. Controversy exists as to the effect of bacterial endotoxin (lipopolysaccharide, or LPS) on the production of O2-. We have injected rabbits with 25 micrograms Escherichia coli LPS intravenously and studied PMN function 18 to 24 hours later. Relative to PMN from sali...
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Mononuclear phagocytic leukocytes, as well as polymorphonuclear leukocytes, produce and release superoxide at rest, and this is stimulated by phagocytosis. Of the mouse monocytic cells studied, alveolar macrophages released the largest amounts of superoxide during phagocytosis, followed by normal peritoneal macrophages. Casein-elicited and "activated" macrophages released smaller quantities. In...
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Tetramethylpyrazine is one of the active ingredients of the Chinese herb Ligusticum wallichii Franchat. By electron spin resonance spin trapping methods, effects of tetramethylpyrazine on superoxide anion and nitric oxide generated by human polymorphonuclear leukocytes were studied. During the respiratory burst of polymorphonuclear leukocytes induced by N-formylmethionyl-leucyl-phenylalanine, t...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1989
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.20.157